THE ROLE OF CYCLIC ADENOSINE MONOPHOSPHATE IN REGULATION MEMBRANE AND THRESHOLD POTENTIALS OF COMMAND NEURONS OF LEARNED SNAILS

Abstract: 

The authors of the article studied the effects of application of nonspecific inhibitor of phosphodiesterase IBMX and membrane permeable analog of cyclic adenosine monophosphate (cAMP) – 8-Br-cAMP on changing of membrane characteristics of command neurons in the preparations of learned and naive snails. It was found out that the increase of cAMP’s concentration by various means led to changing only of membrane potential, but not of threshold potential of studied neurons. These results argue that changes of these parameters are held by different mechanisms. Probably, the adenylate cyclase system of snails takes part in changes of membrane potential, but the exact mechanism is not known. It may mean that these mechanisms are connected with ion channels. 

Key words: 

cAMP, defensive conditioned reflex, membrane potential, threshold potential, IBMX, 8Br-cAMP, snail.

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