THE INFLUENCE OF BLOCKADE P2Y - PURINORECEPTORS ON THE INOTROPIC HEART FUNCTION IN ONTOGENY

Abstract: 

The authors of the article studied the influence of blockers of P2Y-receptors on force of reduction of the myocardium of rats in ontogeny. Using PPADS and a reactive blue-2, blockers of different subtypes P2Y-receptors has revealed age features of influence of antagonists on the contractility activity of a myocar-dium. At 21-daily allowances of infant rats the force of reduction of the myocardium of auricles on PPADS and reactive blue 2 above is higher than at 100-daily allowances. Probably it is connected with the age features regulation influence on the heart and biological stages of maturing organism. 

Key words: 

P2Y-purinoreceptors, heart, PPADS, reactive blue 2, ontogeny.

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