DOSE DEPENDENT EFFECTS OF CARBOCHOLINE ON MYOCARDIAL CANTRACTILITY OF RATS IN POSTNATAL PERIOD

Abstract: 

The dose dependent effects of carbocholine 10-5 to 10-9 mole on myocardial contractility of rats of one, three, six, eight and twenty-week-old were investigated. The negative inotropic effect of carbocholine was evoked in concentration 10-5 mole, except the myocardium of the atria of newborn animals where carbocholine in a concentration of 10-5 did not lead to significant changes. In eight-week-old animals carbocholine in low concentrations increased contractility of myocardium.

Key words: 

heart, myocardial contractility, carbocholine, rat, postnatal period.

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