THE INFLUENCE OF UTP ON CONTRACTILE ACTIVITY OF MYOCARDIUM OF RATS IN ONTOGENY

Abstract: 

The effect of UTP in concentration 10-10-10-6 М on contractile activity of a myocardium was studied in 7-100-day-old rats. The analysis of isometric contraction of myocardial strips demonstrated negative ino-tropic effect of UTP. Physiological concentration of extracellular UTP causes the most inhibition effect on contractile activity of myocardium of 21- and 100-day rats, in comparison with 7-day animals.

Key words: 

purinoreceptors, P2Y-receptors, UTP myocardial, heart, ontogeny.

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